Treatment Etonitazepyne

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Etonitazepyne

Found in:  

Fentanyl, Falsified pharmaceutical opioids

Type/Reason added:  

Nitazene

Relative Potency:  

20 times more potent than fentanyl (6)

Overview

The Effects

Treatment Options

Supportive Care:

Immediate medical attention is crucial in cases of etonitazepyne overdose, with supportive care including assisted ventilation or oxygen therapy to address respiratory depression and hospitalization for close monitoring of the patient’s condition.

Antidote:

Naloxone (Narcan) is the primary antidote used to reverse opioid overdoses. However, due to the extreme potency of etonitazepyne, multiple doses of naloxone may be required.

Pharmacokinetics and Dynamics

Metabolism:

Likely metabolized in the liver via cytochrome P450 enzymes, though specific pathways for etonitazepyne are not well-documented. Other nitazenes often produce active metabolites, prolonging their effects.

Drug-Drug Interactions:

Etonitazepyne poses a high risk of dangerous interactions with central nervous system (CNS) depressants such as benzodiazepines, alcohol, other opioids, and sedative-hypnotics, significantly increasing the likelihood of fatal respiratory depression.