Treatment Menitazene

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Menitazene

Found in:  

Fentanyl

Type/Reason added:  

Nitazene

Relative Potency:  

10 times stronger than morphine (18)

Overview

The Effects

Treatment Options

Supportive Care:

Airway management and assisted ventilation.

Antidote:

Naloxone can reverse the effects of menitazene, though higher or repeated doses may be needed due to its potency.

Pharmacokinetics and Dynamics

Metabolism:

Menitazene is metabolized primarily in the liver through the cytochrome P450 enzyme system. Its exact metabolic pathways are not well-studied, but it is expected to produce metabolites that are excreted in the urine.

Drug-Drug Interactions:

Menitazene poses a high risk of dangerous interactions, particularly with central nervous system depressants such as alcohol, benzodiazepines, or barbiturates. These combinations significantly increase the risk of fatal respiratory depression. Concurrent use with stimulants like cocaine or methamphetamine can lead to unpredictable cardiovascular effects.