Treatment Flunitazene

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Flunitazene

Found in:  

Fentanyl

Type/Reason added:  

Nitazene

Relative Potency:  

About the same as morphine (18)

Overview

The Effects

Treatment Options

Supportive Care:

Oxygen supplementation and airway management.

Antidote:

Naloxone is needed to reverse respiratory depression. Due to Flunitazene’s high potency, multiple naloxone doses may be required.

Pharmacokinetics and Dynamics

Metabolism:

Flunitazene is metabolized in the liver, likely involving cytochrome P450 enzymes. Its metabolites are excreted via the urine.

Drug-Drug Interactions:

Flunitazene has dangerous interactions with other central nervous system depressants, such as alcohol, benzodiazepines, or barbiturates, significantly increasing the risk of respiratory depression and fatal overdose. Drugs affecting liver enzymes (CYP450 inhibitors or inducers) may alter its metabolism and exacerbate its effects or toxicity.