Metodesnitazene

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Metodesnitazene

Found in:  

Fentanyl

Type/Reason added:  

Nitazene

Relative Potency:  

similar to morphine (18)

Overview

The Effects

Treatment Options

Supportive Care:

Maintaining airway patency, oxygen therapy, and mechanical ventilation if necessary.

Antidote:

Naloxone, an opioid receptor antagonist, can be used to reverse life-threatening respiratory depression. Multiple doses of naloxone may be required due to the drug's potency.

Pharmacokinetics and Dynamics

Metabolism:

Metodesnitazene is metabolized in the liver, likely via pathways similar to other nitazenes, though specific details are not well-documented. It is primarily excreted via the kidneys.

Drug-Drug Interactions:

Metodesnitazene's depressant effects are amplified when combined with other CNS depressants, including alcohol, benzodiazepines, and sedatives. This significantly increases the risk of respiratory depression and overdose. Stimulants can mask the sedative effects, leading to unintentional overdosing.