Acryloylfentanyl

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Acryloylfentanyl

Found in:  

Fentanyl

Type/Reason added:  

Synthetic opioid, Fentanyl analog

Relative Potency:  

75% of fentanyl (11), 170 times more potent than morphine (12)

Overview

The Effects

Treatment Options

Supportive Care: Immediate medical intervention is essential. Supportive care includes maintaining the airway, ensuring proper breathing, and monitoring cardiovascular function.

Antidote: Naloxone (Narcan) is the primary antidote for opioid overdoses and can reverse the life-threatening effects of Acryloylfentanyl. Due to its potency, multiple doses of naloxone may be required to manage an overdose effectively.

Pharmacokinetics and Dynamics

Metabolism: Likely metabolized in the liver, involving the CYP450 enzyme system. Its metabolites are excreted through the kidneys.

Drug-Drug Interactions: Strong potential for dangerous interactions with other CNS depressants, significantly increasing the risk of life-threatening respiratory depression when combined with substances like alcohol, benzodiazepines, or other opioids.