N-Desethyl Isotonitazene

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Found in:  

Fentanyl

Type/Reason added:  

Nitazene

Relative Potency:  

N/A

Overview

The Effects

Treatment Options

Supportive Care:

Ensuring a clear airway, providing oxygen, and using mechanical ventilation if needed.

Antidote:

Overdose can be reversed with naloxone, but due to its high potency, multiple doses may be required.

Pharmacokinetics and Dynamics

Metabolism:

The liver metabolizes N-desethyl isotonitazene via cytochrome P450 enzymes, with metabolites excreted in the urine. Because it is an active metabolite, it may prolong opioid effects and contribute to overdose risks.

Drug-Drug Interactions:

Combining it with alcohol, benzodiazepines (Xanax, Valium), or other opioids drastically increases the risk of fatal overdose. CYP enzyme inhibitors may also prolong its effects, leading to greater toxicity.