Nitazene | The JHI

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Nitazene

Found in:  

Fentanyl

Type/Reason added:  

Nitazene

Relative Potency:  

about two times stronger than morphine (18)

Overview

The Effects

Treatment Options

Supportive Care:

Ensuring a clear airway, providing oxygen, and using mechanical ventilation if needed.

Antidote:

Overdose can be reversed with naloxone, but due to its high potency, multiple doses may be required.

Pharmacokinetics and Dynamics

Metabolism:

Nitazenes are metabolized primarily in the liver and eliminated in urine, but their metabolic pathways vary depending on the specific analog. Some nitazenes have longer half-lives than fentanyl, leading to prolonged effects and overdose risk.

Drug-Drug Interactions:

Combining nitazenes with alcohol, benzodiazepines, or other central nervous system depressants drastically increases the risk of fatal respiratory depression. Stimulant use (e.g., methamphetamine, cocaine) can cause unpredictable cardiovascular effects.