THE J HEALTHCARE INITIATIVE
Despropionyl Fentanyl
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Found in:
Fentanyl
Type/Reason added:
Marginally active metabolite of fentanyl and fentanyl analogs
Relative Potency:
N/A
Treatment Options
Supportive Care:
Ensure airway patency and provide oxygen or ventilation as needed.
Antidote:
Naloxone is effective in reversing opioid effects, though standard doses are typically sufficient due to its weak potency.
Pharmacokinetics and Dynamics
Metabolism:
Fentanyl is metabolized to despropionyl fentanyl by liver enzymes (e.g., CYP3A4).
Drug-Drug Interactions:
There is a high potential for dangerous interactions with other CNS depressants, alcohol, opioids, and CYP450 Enzyme Modulators.
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