Etizolam | The JHI

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Etizolam

Found in:  

Fentanyl, BZD

Type/Reason added:  

Short acting DBZD

Relative Potency:  

N/A

Overview

The Effects

Treatment Options

Supportive Care:

In cases of overdose, medical intervention is required, including securing the airway, providing respiratory support, and monitoring vital signs.

Antidote:

Flumazenil, a benzodiazepine receptor antagonist, may be used cautiously to reverse sedative effects, though it carries seizure risks.

Pharmacokinetics and Dynamics

Metabolism:

Etizolam is metabolized in the liver, primarily by the enzyme CYP3A4. Its primary metabolite is alpha-hydroxyetizolam, which is pharmacologically active.

Drug-Drug Interactions:

There is a high potential for dangerous interactions with other CNS depressants, including alcohol, opioids, and other benzodiazepines, which can significantly increase the risk of sedation, respiratory depression, and overdose.