Supportive Care: 

Includes oxygen support, respiratory monitoring, and emergency medical attention, especially if naloxone is not immediately effective.

Antidote: 

Naloxone (Narcan) is the primary antidote and can help reverse respiratory depression. Due to clonitazene’s potency, multiple doses may be necessary.

Pharmacokinetics and Dynamics

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Metabolism: 

Clonitazene is metabolized by the liver, though specific pathways are not well-studied. It is likely broken down similarly to other synthetic opioids.

Drug-Drug Interactions: 

There is a high potential for dangerous interactions with other CNS depressants, including alcohol, benzodiazepines, or other sedatives which can increase overdose risk and can lead to life-threatening respiratory depression.