Adinazolam | The JHI

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Adinazolam

Found in:  

Fentanyl, BZD

Type/Reason added:  

Short acting DBZD

Relative Potency:  

Adinazolam at 50 mg induced more physical and mental sedation than lorazepam (2–4 mg)

Overview

The Effects

Treatment Options

Supportive Care: In case of overdose, immediate medical intervention is crucial. Treatment may include securing the airway, providing ventilation, and monitoring cardiovascular function.

Antidote: Flumazenil is the antidote for benzodiazepine overdose, but its use is carefully managed due to the risk of precipitating withdrawal symptoms in dependent individuals.

Pharmacokinetics and Dynamics:

Metabolism: Adinazolam is metabolized in the liver, where it is converted to its active metabolite, N-desmethyladinazolam. This metabolite is responsible for much of its pharmacological activity.

Drug-Drug Interactions: High potential for dangerous interactions with other CNS depressants, including alcohol, opioids, and other benzodiazepines, which can lead to enhanced sedation and increased risk of respiratory depression.