THE J HEALTHCARE INITIATIVE
Nitazene
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Found in:
Fentanyl
Type/Reason added:
Nitazene
Relative Potency:
about two times stronger than morphine (18)
Description and Classification
Nitazene:
Nitazenes belong to the 2-benzylbenzimidazole class of opioids and act as potent synthetic opioid agonists at the mu-opioid receptor. First developed in the 1950s as potential analgesics, they were never approved for medical use due to their extreme potency and overdose risk.
Relative Potency
Potency:
Nitazenes can be significantly more potent than fentanyl, with some analogs (e.g., isotonitazene, etonitazene) being 20–100 times stronger than fentanyl. Their potency varies depending on the specific compound, but even trace amounts can be lethal.
Why It Is Added
Purpose
Nitazenes are not used in medical practice but have emerged in the illicit drug market as heroin or fentanyl substitutes. Due to their high potency, they increase the risk of accidental overdose, especially when users are unaware of their presence in counterfeit pills or street opioids.
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