THE J HEALTHCARE INITIATIVE
Ocfentanil
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Found in:
Fentanyl
Type/Reason added:
Fentanyl Analog
Relative Potency:
90 times more potent than morphine, 1.7-2.5 times stronger than fentanyl (11,12)
Description and Classification
Ocfentanil:
A synthetic opioid and a derivative of fentanyl. It belongs to the class of ultra-potent opioids, meaning it has an extremely high binding affinity for opioid receptors, leading to intense analgesic and euphoric effects. It is structurally related to fentanyl but is considered even more potent due to modifications that enhance receptor binding.
Relative Potency
Potency:
Ocfentanil is significantly more potent than fentanyl. While exact potency varies, estimates suggest it is around 1.7 to 2.5 times stronger than fentanyl, making it one of the most powerful opioids known. Even microgram doses can cause profound effects, increasing the risk of overdose.
Why It Is Added
Purpose
Medically, ocfentanil has been studied for its potential use as an anesthetic and pain reliever, though it has never been widely approved for therapeutic use. Illicitly, it has been found in counterfeit opioid products and is sometimes mixed with heroin or fentanyl to enhance potency.
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