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4'-Hydroxy nitazene

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Found in: 


Fentanyl

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Type/Reason added: 


Nitazene (benzimidazole opioid)

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Relative Potency: 


N/A

Treatment Options

Supportive Care: Immediate medical intervention is essential. Supportive care includes securing the airway, providing ventilation, and managing circulation.

Antidote: Naloxone (Narcan) is the primary antidote for opioid overdoses and can reverse the life-threatening effects of 4'-Hydroxy Nitazene. Due to its high potency, repeated doses of naloxone may be required to manage an overdose effectively.

Pharmacokinetics and Dynamics

Metabolism: Likely metabolized in the liver, similar to other opioids, involving enzymatic pathways like CYP450.

Drug-Drug Interactions: High risk of dangerous interactions with other CNS depressants, such as benzodiazepines, alcohol, and other opioids, which can significantly increase the risk of fatal respiratory depression.

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