THE J HEALTHCARE INITIATIVE
4'-Hydroxy nitazene
Found in:
Fentanyl
Type/Reason added:
Nitazene (benzimidazole opioid)
Relative Potency:
N/A
Treatment Options
Supportive Care: Immediate medical intervention is essential. Supportive care includes securing the airway, providing ventilation, and managing circulation.
Antidote: Naloxone (Narcan) is the primary antidote for opioid overdoses and can reverse the life-threatening effects of 4'-Hydroxy Nitazene. Due to its high potency, repeated doses of naloxone may be required to manage an overdose effectively.
Pharmacokinetics and Dynamics
Metabolism: Likely metabolized in the liver, similar to other opioids, involving enzymatic pathways like CYP450.
Drug-Drug Interactions: High risk of dangerous interactions with other CNS depressants, such as benzodiazepines, alcohol, and other opioids, which can significantly increase the risk of fatal respiratory depression.
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