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4-Fluorofentanyl

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Found in: 


Fentanyl

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Type/Reason added: 


Synthetic opioid, Fentanyl analog / Opioid effects

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Relative Potency: 


analgesic potency:

about 30% of fentanyl (11), 16 times more potent than morphine (12)

Treatment Options

Supportive Care: Immediate medical attention is critical. Supportive care includes maintaining airway, breathing, and circulation.

Antidote: Naloxone (Narcan) is the primary treatment for opioid overdose and can reverse the life-threatening effects of 4-Fluorofentanyl. Due to its high potency, multiple doses of naloxone may be required to counteract the overdose.

Effects:

  • Opioid Effects: Similar to fentanyl, including intense analgesia, euphoria, sedation, and severe respiratory depression.

  • Adverse Effects: High risk of overdose and death due to its potent respiratory depressant effects. Other side effects may include drowsiness, dizziness, nausea, vomiting, and constipation.

Pharmacokinetics and Dynamics

  • Metabolism: Primarily metabolized in the liver, similar to fentanyl, likely involving the CYP3A4 enzyme.

  • Drug-Drug Interactions: Strong potential for dangerous interactions with other CNS depressants, such as alcohol, benzodiazepines, and other opioids, increasing the risk of life-threatening respiratory depression.

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