THE J HEALTHCARE INITIATIVE
3-hydroxyphenazepam
Found in:
Opioids, BZD
Type/Reason added:
DBZD/ Enhance inhibitory effects of opioids
Relative Potency:
N/A
Treatment Options
Supportive Care: The primary approach to managing acute benzodiazepine intoxication involves supportive care, including maintaining airway, breathing, and circulation.
Antidote: While flumazenil can reverse benzodiazepine effects, its use is typically not recommended due to the risk of precipitating withdrawal symptoms, lowering seizure threshold, and causing cardiac dysrhythmias. Flumazenil should be used with caution and only in specific cases where the benefits outweigh the risks.
Pharmacokinetics and Dynamics
Metabolism: It is primarily metabolized in the liver, likely involving cytochrome P450 enzymes.
Drug-Drug Interactions: Benzodiazepines can interact with other CNS depressants, increasing the risk of severe sedation, respiratory depression, and other adverse effects.
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