Airway Management and Oxygenation.

Antidote: 

While the antidote flumazenil can effectively reverse benzodiazepine-mediated sedation, its use in acute benzodiazepine intoxication is not recommended due to the potential risks that may outweigh benefits as it can precipitate acute withdrawal syndromes, lower seizure threshold, and cause cardiac dysrhythmias.

Pharmacokinetics and Dynamics

Metabolism: 

Meclonazepam is metabolized in the liver, likely through pathways involving the cytochrome P450 enzyme system. Its metabolites are excreted via the urine. Due to its long half-life, it can remain active in the body for an extended period, contributing to cumulative effects with repeated use.

Drug-Drug Interactions: 

Meclonazepam has dangerous interactions with other central nervous system depressants, including alcohol, opioids, and barbiturates, which significantly increase the risk of respiratory depression and fatal overdose. It may also interact with medications that affect liver enzymes, altering its metabolism.