Treatment Isotonitazepyne

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Isotonitazepyne

Found in:  

Fentanyl

Type/Reason added:  

Nitazene

Relative Potency:  

more than 20 times stronger than fentanyl

Overview

The Effects

Treatment Options

Supportive Care:

Assisted Ventilation

Antidote:

Naloxone, though multiple doses may be required due to its potency.

Pharmacokinetics and Dynamics

Metabolism:

Isotonitazepyne is metabolized in the liver, likely involving the cytochrome P450 enzyme system, though its specific pathways and metabolites are not yet well-studied. Metabolites are excreted primarily through the urine.

Drug-Drug Interactions:

Isotonitazepyne has dangerous interactions with central nervous system depressants, including alcohol, benzodiazepines, and other sedatives, which significantly increase the risk of fatal respiratory depression. Stimulants like cocaine or methamphetamine may lead to cardiovascular strain and unpredictable effects.