Treatment Isotonitazene

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Isotonitazene

Found in:  

Fentanyl

Type/Reason added:  

Nitazene

Relative Potency:  

500 times stronger than morphine (18)

similar to fentanyl (24)

Overview

The Effects

Treatment Options

Supportive Care:

Airway management and respiratory support.

Antidote:

Naloxone can reverse its effects, but multiple doses may be required due to its high potency.

Pharmacokinetics and Dynamics

Metabolism:

Mainly metabolized in the liver and excreted in urine as N-dealkylated product.

Drug-Drug Interactions:

Isotonitazene poses a high risk of dangerous interactions, especially with other CNS depressants like alcohol, benzodiazepines, or barbiturates, which exacerbate respiratory depression. Stimulants such as cocaine or methamphetamine can create unpredictable effects, increasing cardiovascular strain and the risk of adverse outcomes.