Treatment Flunitrazolam

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Flunitrazolam

Found in:  

Fentanyl, BZD

Type/Reason added:  

DBZD

Relative Potency:  

N/A

Overview

The Effects

Treatment Options

Supportive Care:

Respiratory and cardiovascular monitoring.

Antidote:

Flumazenil can be used to reverse the effects, but it carries a risk of precipitating withdrawal or seizures in dependent individuals.

Pharmacokinetics and Dynamics

Metabolism:

Flunitrazolam is metabolized in the liver, likely through the cytochrome P450 enzyme system (e.g., CYP3A4). Its metabolites are excreted via the urine.

Drug-Drug Interactions:

Flunitrazolam has significant interactions with other central nervous system depressants, such as alcohol, opioids, and sedative-hypnotics, dramatically increasing the risk of respiratory depression and fatal overdose. It may also interact with drugs that inhibit or induce CYP450 enzymes, altering its metabolism and effects.