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Alfentanil

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Found in: 


Fentanyl

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Type/Reason added: 


Fentanyl analog, 

Opioid effects

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Relative Potency: 


analgesic potency:

72 times stronger than morphine, 10-20% potency of fentanyl (12)

Treatment Options

Supportive Care:

In the case of overdose or adverse reactions, immediate medical intervention is crucial. Supportive care includes maintaining airway, breathing, and circulation.

Antidote:

Naloxone (Narcan) is the primary antidote for opioid overdoses, including alfentanil. Given its short half-life, multiple doses of naloxone may be required to manage an overdose effectively.

Pharmacokinetics and Dynamics:

Metabolism:

Alfentanil is metabolized primarily in the liver via the CYP3A4 enzyme. It has a shorter duration of action and a rapid onset compared to fentanyl due to its lower lipid solubility.

  • Half-life: Shorter than fentanyl, with an elimination half-life of around 90 minutes.

Drug-Drug Interactions:

High risk of dangerous interactions with other CNS depressants, such as benzodiazepines, alcohol, and other opioids, which can increase sedation and the risk of respiratory depression.

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